Prokaryotic Na⁺/H⁺ Exchangers-Transport Mechanism and Essential Residues.

ABSTRACT: Na⁺/H⁺ exchangers are essential for Na⁺ and pH homeostasis in all organisms. Human Na⁺/H⁺ exchangers are of high medical interest, and insights into their structure and function are aided by the investigation of prokaryotic homologues. Most prokaryotic Na⁺/H⁺ exchangers belong to either the Cation/Proton Antiporter (CPA) superfamily, the Ion Transport (IT) superfamily, or the Na⁺-translocating Mrp transporter superfamily. Several structures have been solved so far for CPA and Mrp members, but none for the IT members. NhaA from E. coli has served as the prototype of Na⁺/H⁺ exchangers due to the high amount of structural and functional data available. Recent structures from ot

SUBMITTER: Patino-Ruiz M 

PROVIDER: S-EPMC9408914 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature