Collagen-Sealed Polyester Vascular Prostheses Functionalized by Polycatecholamine Coatings.

ABSTRACT: Collagen-sealed polyester (PET) prostheses are commonly used in reconstructive vascular surgery due to their self-sealing properties. To prevent post-surgical infection, different modification methods have been tested but so far none have showed long-term satisfactory efficiency. For this reason, in the present study, a commercial collagen-sealed PET prosthesis was coated by a highly adhesive poly (L-DOPA) layer maintaining the sealing protein without losing the original properties and functionality. This modified (as proven by SEM, FTIR, XPS and contact angle) graft exhibited comparable wettability and elasticity as pristine commercial graft, as well as reduced hemolysis-inducing effect, lowered toxicity against human endothelial cells and reduced toxicity in Danio rerio model. Poly (L-DO

SUBMITTER: Michalicha A 

PROVIDER: S-EPMC9409057 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature