Mouse Models for Immune Checkpoint Blockade Therapeutic Research in Oral Cancer.

ABSTRACT: The most prevalent oral cancer globally is oral squamous cell carcinoma (OSCC). The invasion of adjacent bones and the metastasis to regional lymph nodes often lead to poor prognoses and shortened survival times in patients with OSCC. Encouraging immunotherapeutic responses have been seen with immune checkpoint inhibitors (ICIs); however, these positive responses to monotherapy have been limited to a small subset of patients. Therefore, it is urgent that further investigations into optimizing immunotherapies are conducted. Areas of research include identifying novel immune checkpoints and targets and tailoring treatment programs to meet the needs of individual patients. Furthermore, the advancement of combination therapies against OSCC is also critical. Thus, additional studies are needed

SUBMITTER: Chiu WC 

PROVIDER: S-EPMC9409124 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature