The Kinesin Gene KIF26B Modulates the Severity of Post-Traumatic Heterotopic Ossification.

ABSTRACT: The formation of pathological bone deposits within soft tissues, termed heterotopic ossification (HO), is common after trauma. However, the severity of HO formation varies substantially between individuals, from relatively isolated small bone islands through to extensive soft tissue replacement by bone giving rise to debilitating symptoms. The aim of this study was to identify novel candidate therapeutic molecular targets for severe HO. We conducted a genome-wide scan in men and women with HO of varying severity following hip replacement for osteoarthritis. HO severity was dichotomized as mild or severe, and association analysis was performed with adjustment for age and sex. We next confirmed expression of the gene encoded by the lead signal in human bone and in primary human mesenchymal s

SUBMITTER: Pickering GAE 

PROVIDER: S-EPMC9409126 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature