(-)-Epicatechin Is a Biased Ligand of Apelin Receptor.

ABSTRACT: (-)-Epicatechin (EC) is part of a large family of biomolecules called flavonoids and is widely distributed in the plant kingdom. Several studies have shown the beneficial effects of EC consumption. Many of these reported effects are exerted by activating the signaling pathways associated with the activation of two specific receptors: the G protein-coupled estrogen receptor (GPER), a transmembrane receptor, and the pregnane X receptor (PXR), which is a nuclear receptor. However, the effects of EC are so diverse that these two receptors cannot describe the complete phenomenon. The apelin receptor or APLNR is classified within the G protein-coupled receptor (GPCR) family, and is capable of activating the G protein canonical pathways and the β-arrestin transducer, which participates in the phe

SUBMITTER: Portilla-Martinez A 

PROVIDER: S-EPMC9409145 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature