Dataset Information

Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects.

ABSTRACT:

Objectives

This review article aims to describe some of the roles of Matrix metalloproteinases (MMPs) in enamel, dentine, dental caries, hybrid layer degradation, pulp and periodontal tissues, throwing light on their current inhibitors. The article addresses the potential of MMPs to serve as biomarkers with diagnostic and therapeutic value.

Design

The sections of this review discuss MMPs' involvement in developmental, remodeling, degradational and turnover aspects of dental and periodontal tissues as well as their signals in the pathogenesis, progress of different lesions and wound healing of these tissues. The literature was searched for original research articles, review articles and theses. The literature search was conducted in PubMed and MEDLINE for articles published in the last 20 years.

Results

119 published papers, two textbooks and two doctoral theses were selected for preparing the current review.

Conclusions

MMPs are significant proteases, of evident contribution in dental and periapical tissue development, health and disease processes, with promising potential for use as diagnostic and prognostic disease biomarkers. Continuing understanding of their role in pathogenesis and progress of different dental, periapical and periodontal lesions, as well as in dentine-pulp wound healing could be a keystone to future diagnostic and therapeutic regimens.

SUBMITTER: Elgezawi M

PROVIDER: S-EPMC9409155 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects.

Elgezawi Moataz M Haridy Rasha R Almas Khalid K Abdalla Moamen A MA Omar Omar O Abuohashish Hatem H Elembaby Abeer A Christine Wölfle Uta U Siddiqui Yasir Y Kaisarly Dalia D

International journal of molecular sciences 20220811 16

<h4>Objectives</h4>This review article aims to describe some of the roles of Matrix metalloproteinases (MMPs) in enamel, dentine, dental caries, hybrid layer degradation, pulp and periodontal tissues, throwing light on their current inhibitors. The article addresses the potential of MMPs to serve as biomarkers with diagnostic and therapeutic value.<h4>Design</h4>The sections of this review discuss MMPs' involvement in developmental, remodeling, degradational and turnover aspects of dental and pe ...[more]

PMID: 36012195

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Dataset Information

Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects.

Objectives

Design

Results

Conclusions

Publications

Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects.

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