SARS-CoV-2 and Immunity: Natural Infection Compared with Vaccination.

ABSTRACT: Recently, the protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies. We investigated the anti-spike IgG levels and SARS-CoV-2-specific T cells in 125 donors (90 vaccinated with four different vaccine platforms, 16 individuals with a previous natural infection, and 19 not vaccinated donors who did not report previous SARS-CoV-2 infections). Our data show that anti-spike IgG titers were similar between naturally infected subjects and those vaccinated with adenoviral vector vaccines. Of note, all immunized donors produced memory CD4⁺ and/or CD8⁺ T cells. A sustained polyfunctionality of SARS-CoV-2-specific T cells in all immunized donors was also demonstrated. Altogether, our data suggest that the natural

SUBMITTER: Vespa S 

PROVIDER: S-EPMC9409314 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature