Disrupted Decision-Making: EcoHIV Inoculation in Cocaine Dependent Rats.

ABSTRACT: Independently, chronic cocaine use and HIV-1 viral protein exposure induce neuroadaptations in the frontal-striatal circuit as evidenced by both clinical and preclinical studies; how the frontal-striatal circuit responds to HIV-1 infection following chronic drug use, however, has remained elusive. After establishing experience with both sucrose and cocaine self-administration, a pretest-posttest experimental design was utilized to evaluate preference judgment, a simple form of decision-making dependent upon the integrity of frontal-striatal circuit function. During the pretest assessment, male rats exhibited a clear preference for cocaine, whereas female animals preferred sucrose. Two posttest evaluations (3 days and 6 weeks post inoculation) revealed that, independent of biological sex, i

SUBMITTER: McLaurin KA 

PROVIDER: S-EPMC9409394 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature