Neuronal Roles of the Multifunctional Protein Dipeptidyl Peptidase-like 6 (DPP6).

ABSTRACT: The concerted action of voltage-gated ion channels in the brain is fundamental in controlling neuronal physiology and circuit function. Ion channels often associate in multi-protein complexes together with auxiliary subunits, which can strongly influence channel expression and function and, therefore, neuronal computation. One such auxiliary subunit that displays prominent expression in multiple brain regions is the Dipeptidyl aminopeptidase-like protein 6 (DPP6). This protein associates with A-type K⁺ channels to control their cellular distribution and gating properties. Intriguingly, DPP6 has been found to be multifunctional with an additional, independent role in synapse formation and maintenance. Here, we feature the role of DPP6 in regulating neuronal function in the contex

SUBMITTER: Malloy C 

PROVIDER: S-EPMC9409431 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature