Anti-Inflammatory Activity of Cajanin, an Isoflavonoid Derivative Isolated from Canavalia lineata Pods.

ABSTRACT: The bioactive components of Canavalia lineata (Thunb.) DC pods were investigated using bioactivity-guided isolation, and the chemical structures of flavonoids 1-3, isoflavonoid derivatives 4-11, and phenolic compounds 12 and 13 were identified by comparing NMR, MS, and CD spectral data with previously reported spectroscopic data. Compounds 1-13 were evaluated for their anti-inflammatory effects on LPS-stimulated RAW264.7 macrophages. Among these compounds, the isoflavonoid derivative cajanin (7) exhibited the most potent anti-inflammatory activity (IC₅₀ of NO = 19.38 ± 0.05 µM; IC₅₀ of IL-6 = 7.78 ± 0.04 µM; IC₅₀ of TNF-α = 26.82 ± 0.11 µM), exerting its anti-inflammatory effects by suppr

SUBMITTER: Hong SJ 

PROVIDER: S-EPMC9409483 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature