Tamoxifen-resistant breast cancer cells exhibit reactivity with Wisteria floribunda agglutinin.

ABSTRACT: Glycosylation is one of the most important post-translational modifications of cell surface proteins involved in the proliferation, metastasis and treatment resistance of cancer cells. However, little is known about the role of glycosylation as the mechanism of breast cancer cell resistance to endocrine therapy. Herein, we aimed to identify the glycan profiles of tamoxifen-resistant human breast cancer cells, and their potential as predictive biomarkers for endocrine therapy. We established tamoxifen-resistant cells from estrogen receptor-positive human breast cancer cell lines, and their membrane-associated proteins were subjected to lectin microarray analysis. To confirm differential lectin binding to cellular glycoproteins, we performed lectin blotting analyses after electrophoretic sep

SUBMITTER: Hlaing MT 

PROVIDER: S-EPMC9409572 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature