Quantitative bile and serum proteomics for the screening and differential diagnosis of primary sclerosing cholangitis.

ABSTRACT:

Background

Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by biliary strictures, cholestasis, and a markedly increased risk of cholangiocarcinoma. New markers for the screening and differential diagnosis of PSC are needed. In this pilot study, we have analyzed both the bile and serum proteomic profiles of 80 PSC patients and non-PSC controls (n = 6 for bile and n = 18 for serum).

Aim

The aim of this study was to discover candidates for new biomarkers for the differential diagnosis of PSC.

Methods

Bile and serum samples were processed and subsequently analyzed using ultra performance liquid chromatography-ultra definition mass spectrometry (UPLC-UDMSE). Further analysis included statistical analyses such as receiver operating characterist

SUBMITTER: Holm M 

PROVIDER: S-EPMC9409575 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature