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Anti-inflammatory Polyketides from the Marine-Derived Fungus Eutypella scoparia.

ABSTRACT: Three new polyketides, eutyketides A and B (1 and 2) and cytosporin X (3), along with four known compounds (4-7), were obtained from the marine-derived fungus Eutypella scoparia. The planar structures of 1 and 2 were elucidated by extensive HRMS and 1D and 2D NMR analyses. Their relative configurations of C-13 and C-14 were determined with chemical conversions by introducing an acetonylidene group. The absolute configurations of 1-3 were determined by comparing their experimental electronic circular dichroism (ECD) data with their computed ECD results. All of the isolated compounds were tested for their anti-inflammatory activities on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages. Compounds 5 and 6 showed stronger anti-inflammatory activities than the other compounds, with the inhibition of 49.0% and 54.9% at a concentration of 50.0 µg/mL, respectively.

SUBMITTER: Zhang YH

PROVIDER: S-EPMC9410037 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Anti-inflammatory Polyketides from the Marine-Derived Fungus Eutypella scoparia.

Zhang Ya-Hui YH Du Hui-Fang HF Gao Wen-Bin WB Li Wan W Cao Fei F Wang Chang-Yun CY

Marine drugs 20220728 8

Three new polyketides, eutyketides A and B (1 and 2) and cytosporin X (3), along with four known compounds (4-7), were obtained from the marine-derived fungus Eutypella scoparia. The planar structures of 1 and 2 were elucidated by extensive HRMS and 1D and 2D NMR analyses. Their relative configurations of C-13 and C-14 were determined with chemical conversions by introducing an acetonylidene group. The absolute configurations of 1-<b ...[more]

PMID: 36005490

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