Improved Plasma Lipids, Anti-Inflammatory Activity, and Microbiome Shifts in Overweight Participants: Two Clinical Studies on Oral Supplementation with Algal Sulfated Polysaccharide.

ABSTRACT: Seaweed polysaccharides in the diet may influence both inflammation and the gut microbiome. Here we describe two clinical studies with an Ulva sp. 84-derived sulfated polysaccharide-"xylorhamnoglucuronan" (SXRG84)-on metabolic markers, inflammation, and gut flora composition. The first study was a double-blind, randomized placebo-controlled trial with placebo, and either 2 g/day or 4 g/day of SXRG84 daily for six weeks in 64 overweight or obese participants (median age 55 years, median body mass index (BMI) 29 kg/m²). The second study was a randomized double-blind placebo-controlled crossover trial with 64 participants (median BMI 29 kg/m², average age 52) on placebo for six weeks and then 2 g/day of SXRG84 treatment for six weeks, or vice versa. In Study 1, th

SUBMITTER: Roach LA 

PROVIDER: S-EPMC9410082 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature