The Effect of Environment on the Evolution and Proliferation of Protocells of Increasing Complexity.

ABSTRACT: The formation, growth, division and proliferation of protocells containing RNA strands is an important step in ensuring the viability of a mixed RNA-lipid world. Experiments and computer simulations indicate that RNA encapsulated inside protocells can favor the protocell, promoting its growth while protecting the system from being over-run by selfish RNA sequences. Recent work has also shown that the rolling-circle replication mechanism can be harnessed to ensure the rapid growth of RNA strands and the probabilistic emergence and proliferation of protocells with functionally diverse ribozymes. Despite these advances in our understanding of a primordial RNA-lipid world, key questions remain about the ideal environment for the formation of protocells and its role in regulating the proliferat

SUBMITTER: Roy S 

PROVIDER: S-EPMC9410160 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature