Towards Treatable Traits for Pulmonary Fibrosis.

ABSTRACT: Interstitial lung diseases (ILD) are a heterogeneous group of disorders, of which many have the potential to lead to progressive pulmonary fibrosis. A distinction is usually made between primarily inflammatory ILD and primarily fibrotic ILD. As recent studies show that anti-fibrotic drugs can be beneficial in patients with primarily inflammatory ILD that is characterized by progressive pulmonary fibrosis, treatment decisions have become more complicated. In this perspective, we propose that the 'treatable trait' concept, which is based on the recognition of relevant exposures, various treatable phenotypes (disease manifestations) or endotypes (shared molecular mechanisms) within a group of diseases, can be applied to progressive pulmonary fibrosis. These targets for medical intervention ca

SUBMITTER: Hoffman TW 

PROVIDER: S-EPMC9410230 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature