Pharmacogenomics of Monoclonal Antibodies for the Treatment of Rheumatoid Arthritis.

ABSTRACT: Precision medicine refers to a highly individualized and personalized approach to patient care. Pharmacogenomics is the study of how an individual's genomic profile affects their drug response, enabling stable and effective drug selection, minimizing side effects, and maximizing therapeutic efficacy. Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation in the joints. It mainly starts in peripheral joints, such as the hands and feet, and progresses to large joints, which causes joint deformation and bone damage due to inflammation of the synovial membrane. Here, we review various pharmacogenetic studies investigating the association between clinical response to monoclonal antibody therapy and their target genetic polymorphisms. Numerous papers have reported th

SUBMITTER: Lim SH 

PROVIDER: S-EPMC9410311 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature