Neutrophils incite and macrophages avert electrical storm after myocardial infarction.

ABSTRACT: Sudden cardiac death, arising from abnormal electrical conduction, occurs frequently in patients with coronary heart disease. Myocardial ischemia simultaneously induces arrhythmia and massive myocardial leukocyte changes. In this study, we optimized a mouse model in which hypokalemia combined with myocardial infarction triggered spontaneous ventricular tachycardia in ambulatory mice, and we showed that major leukocyte subsets have opposing effects on cardiac conduction. Neutrophils increased ventricular tachycardia via lipocalin-2 in mice, whereas neutrophilia associated with ventricular tachycardia in patients. In contrast, macrophages protected against arrhythmia. Depleting recruited macrophages in Ccr2 ^-/- mice or all macrophage subsets with Csf1 receptor inhibi

SUBMITTER: Grune J 

PROVIDER: S-EPMC9410341 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature