Proton Pump Inhibitors Use and Risk of Preeclampsia: A Meta-Analysis.

ABSTRACT: Evidence from preclinical studies suggests a preventive effect of proton pump inhibitors (PPIs) in preeclampsia. Recently, several epidemiological studies have described a conflicting association between the use of PPIs during pregnancy and preeclampsia risk. This study aimed to evaluate the association between PPI use and the risk of preeclampsia. We searched databases, including MEDLINE, Embase, Scopus, Web of Science Core Collection, Emcare, CINAHL, and the relevant grey literature from inception until 13 September 2021. Studies reporting the preeclampsia risk with the use of PPIs were eligible for inclusion. Literature screening, data extraction, and the risk of bias assessment were performed independently by two investigators. Random-effect meta-analysis was performed to generate rela

SUBMITTER: Hussain S 

PROVIDER: S-EPMC9410414 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature