A network pharmacology approach to identify the mechanisms and molecular targets of curcumin against Alzheimer disease.

ABSTRACT:

Background

Alzheimer disease (AD) is a degenerative brain disease, which may lead to severe memory loss and other cognitive disorders. However, few effective drugs are available in the clinic at present. Curcumin, a major ingredient of traditional Chinese medicine, Curcuma Longa, has various pharmacological activities. Therefore, exploring clinical drugs based on the inhibition of AD pathological features is imperative.

Methods

First, we utilized the HERB database and Swisstarget Prediction database to get the related targets of curcumin and intersected with the AD targets. The intersection targets were used to construct the protein-protein interaction network and performed gene ontology and kyoto encyclopedia of genes and genomes analyses. Further, we obtained targets of cu

SUBMITTER: Wu X 

PROVIDER: S-EPMC9410577 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature