Key pathways and genes in hepatitis B virus-related liver inflammation: Expression profiling and bioinformatics analysis.

ABSTRACT: Chronic hepatitis B virus infection has become a major public health issue worldwide, which can lead to liver inflammation, fibrosis, and hepatocellular carcinoma. According to the inflammation activity, liver tissues can be divided into 5 grades (G0-G4). However, the mechanism of the development of liver inflammation remains unclear. In our study, expression profiling by microarray and bioinformatics technology was used to systemically identify differentially expressed genes (DEGs) between low grades (G0-G1) and high (G2-G4) grades of liver inflammation. Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, and protein-protein interaction network construction were performed for further identification of the key functions, pathways, an

SUBMITTER: Zhao JY 

PROVIDER: S-EPMC9410593 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature