Screening of co-pathogenic genes of non-alcoholic fatty liver disease and hepatocellular carcinoma.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is a risk factor for hepatocellular carcinoma (HCC). However, its carcinogenic mechanism is still unclear, looking for both diseases' transcriptome levels, the same changes as we are looking for NAFLD may provide a potential mechanism of action of HCC. Thus, our study aimed to discover the coexisting pathogenic genes of NAFLD and HCC.

Methods

We performed a variance analysis with public data for both diseases. At the same time, weighted gene correlation network analysis (WGCNA) was used to find highly correlated gene modules in both diseases. The darkturquoise gene module was found to be highly correlated with both diseases. Based on the diagnosis related module genes and the differential genes of the two diseases, we cons

SUBMITTER: Chen T 

PROVIDER: S-EPMC9410624 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature