Multiple Calcium Channel Types with Unique Expression Patterns Mediate Retinal Signaling at Bipolar Cell Ribbon Synapses.

ABSTRACT: Retinal bipolar cells (BCs) compose the canonical vertical excitatory pathway that conveys photoreceptor output to inner retinal neurons. Although synaptic transmission from BC terminals is thought to rely almost exclusively on Ca²⁺ influx through voltage-gated Ca²⁺ (Ca_V) channels mediating L-type currents, the molecular identity of Ca_V channels in BCs is uncertain. Therefore, we combined molecular and functional analyses to determine the expression profiles of Ca_V α₁, β, and α₂δ subunits in mouse rod bipolar (RB) cells, BCs from which the dynamics of synaptic transmission are relatively well-characterized. We found significant heterogeneity in Ca_V subunit expression within the RB population from mice o

SUBMITTER: Zhang G 

PROVIDER: S-EPMC9410755 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature