Deletion of the P/Q-type calcium channel from serotonergic neurons drives male aggression in mice.

ABSTRACT: Aggressive behavior is one of the most conserved social interactions in nature and serves as a crucial evolutionary trait. Serotonin (5-HT) plays a key role in the regulation of our emotions such as anxiety and aggression, but which molecules and mechanisms in the serotonergic system are involved in violent behavior is still unknown. In this study we show that deletion of the P/Q-type calcium channel selectively from serotonergic neurons in the dorsal raphe nuclei (DRN) augments aggressive behavior in male mice, while anxiety is not affected. These mice demonstrated increased induction of the immediate early gene c-fos and in vivo serotonergic firing activity in the DRN. The ventrolateral part of the ventromedial hypothalamus (VHMvl) is also a prominent region of the brain me

SUBMITTER: Bohne P 

PROVIDER: S-EPMC9410759 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature