Elevated serum IL-10 is associated with severity of neonatal encephalopathy and adverse early childhood outcomes.

ABSTRACT:

Background

Neonatal encephalopathy (NE) contributes substantially to child mortality and disability globally. We compared cytokine profiles in term Ugandan neonates with and without NE, with and without perinatal infection or inflammation and identified biomarkers predicting neonatal and early childhood outcomes.

Methods

In this exploratory biomarker study, serum IL-1α, IL-6, IL-8, IL-10, TNFα, and VEGF (<12 h) were compared between NE and non-NE infants with and without perinatal infection/inflammation. Neonatal (severity of NE, mortality) and early childhood (death or neurodevelopmental impairment to 2.5 years) outcomes were assessed. Predictors of outcomes were explored with multivariable linear and logistic regression and receiver-operating characteristic analyses.

Re

SUBMITTER: Pang R 

PROVIDER: S-EPMC9411052 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature