Pharmacometric approach to assist dosage regimen design in neonates undergoing therapeutic hypothermia.

ABSTRACT:

Background

Therapeutic hypothermia (TH) is the treatment of choice for neonates diagnosed with perinatal asphyxia (PA). Dosing recommendations of various therapeutic agents including antimicrobials were not specifically available for the neonates undergoing TH.

Methods

A systematic search methodology was used to identify pharmacokinetic (PK) studies of antimicrobials during TH. Antimicrobials with multiple PK studies were identified to create a generalizable PK model. Pharmacometric simulations were performed using the PUMAS software platform to reproduce the results of published studies. A suitable model that could reproduce the results of all other published studies was identified. With the help of a generalizable model, an optimal dosage regimen was designed considering t

SUBMITTER: Matcha S 

PROVIDER: S-EPMC9411058 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature