Endogenous erythropoietin at birth is associated with neurodevelopmental morbidity in early childhood.

ABSTRACT:

Background

New biomarkers that predict later neurodevelopmental morbidity are needed. This study evaluated the associations between umbilical cord serum erythropoietin (us-EPO) and neurodevelopmental morbidity by the age of 2-6.5 years in a Finnish cohort.

Methods

This study included 878 non-anomalous children born alive in 2012 to 2016 in Helsinki University Hospitals and whose us-EPO concentration was determined at birth. Data of these children were linked to data from the Finnish Medical Birth Register and the Finnish Hospital Discharge Register. Neurodevelopmental morbidity included cerebral palsy, epilepsy, intellectual disability, autism spectrum disorder, sensorineural defects, and minor neurodevelopmental disorders.

Results

In the cohort including both term an

SUBMITTER: Rancken EJ 

PROVIDER: S-EPMC9411059 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature