Developmental depression-to-facilitation shift controls excitation-inhibition balance.

ABSTRACT: Changes in the short-term dynamics of excitatory synapses over development have been observed throughout cortex, but their purpose and consequences remain unclear. Here, we propose that developmental changes in synaptic dynamics buffer the effect of slow inhibitory long-term plasticity, allowing for continuously stable neural activity. Using computational modeling we demonstrate that early in development excitatory short-term depression quickly stabilises neural activity, even in the face of strong, unbalanced excitation. We introduce a model of the commonly observed developmental shift from depression to facilitation and show that neural activity remains stable throughout development, while inhibitory synaptic plasticity slowly balances excitation, consistent with experimental observation

SUBMITTER: Jia DW 

PROVIDER: S-EPMC9411206 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature