Circulating miR-200 family as predictive markers during systemic therapy of metastatic breast cancer.

ABSTRACT:

Purpose

Circulating miRNAs can provide valid prognostic and predictive information for breast cancer diagnosis and subsequent management. They may comprise quintessential biomarkers that can be obtained minimally invasively from liquid biopsy in metastatic breast cancer patients. Therefore, they would be clinically crucial for monitoring therapy response, with the goal of detecting early relapse. This study investigated miRNA expression in patients with early and/or late relapse, and the predictive value for assessing overall (OS) and progression-free survival (PFS).

Methods

Forty-seven patients with metastatic breast cancer from the University Women's Hospital Heidelberg were enrolled in this study. Expression of miR-200a, miR-200b, miR-200c, miR-141, and miR-429 was analyz

SUBMITTER: Fischer C 

PROVIDER: S-EPMC9411224 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature