In-line sample concentration in capillary electrophoresis by cyclodextrin to admicelle microextraction.

ABSTRACT: Cyclodextrins (CDs) as a pseudophase in pseudophase-to-pseudophase microextraction (P²ME) in capillary zone electrophoresis (CZE) are proposed. In this P²ME mode called CD to admicelle ME, a long plug of dilute analyte solution prepared in cetyltrimethylammonium bromide (CTAB) at the critical micellar concentration was injected into the capillary. This formed CTAB admicelles at the interface between the solution and the negatively charged capillary surface, where the analytes were trapped. The injection of CD solution released the admicelles and the analytes from the capillary surface due to the formation of stable CD/CTAB inclusion complexes. The analytes are concentrated at the CD front during injection and voltage separation. Various neutral CDs were found to be ef

SUBMITTER: Vaas APJP 

PROVIDER: S-EPMC9411250 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature