Longitudinal Changes in Global Cerebral Blood Flow in Cognitively Normal Older Adults: A Phase-Contrast MRI Study.

ABSTRACT:

Background

Characterization of blood supply changes in older individuals is important in understanding brain aging and diseases. However, prior studies largely focused on cross-sectional design, thus change in cerebral blood flow (CBF) could not be assessed on an individual level.

Purpose

To evaluate longitudinal short-term changes in global CBF in cognitively normal older adults.

Study type

Prospective, longitudinal, and cohort.

Population

One-hundred twenty-seven cognitive-normal participants (mean age 69 ± 7 years, 47 males) underwent serial MRI with an average follow-up time of 2.1 years.

Field strength/sequence

3 T phase-contrast (PC), three-dimensional magnetization-prepared-rapid-acquisition-of-gradient-echo (MPRAGE) and fluid-attenuated inversion

SUBMITTER: Han H 

PROVIDER: S-EPMC9411265 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature