Naloxone Co-Dispensing with Opioids: a Cluster Randomized Pragmatic Trial.

ABSTRACT:

Background

Although naloxone prevents opioid overdose deaths, few patients prescribed opioids receive naloxone, limiting its effectiveness in real-world settings. Barriers to naloxone prescribing include concerns that naloxone could increase risk behavior and limited time to provide necessary patient education.

Objective

To determine whether pharmacy-based naloxone co-dispensing affected opioid risk behavior. Secondary objectives were to assess if co-dispensing increased naloxone acquisition, increased patient knowledge about naloxone administration, and affected opioid dose and other substance use.

Design

Cluster randomized pragmatic trial of naloxone co-dispensing.

Setting

Safety-net health system in Denver, Colorado, between 2017 and 2020.

Participants

SUBMITTER: Binswanger IA 

PROVIDER: S-EPMC9411391 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature