Expression and associated epigenetic mechanisms of the Ca²⁺-signaling genes in breast cancer subtypes and epithelial-to-mesenchymal transition.

ABSTRACT: Breast cancer-associated deaths are related mainly to specific molecular subtypes and the presence of metastasis. The Epithelial-to-Mesenchymal Transition (EMT) and Ca²⁺ signaling pathways are involved in breast cancer metastasis, and they are regulated in part by epigenetic mechanisms. Moreover, activation of EMT modulates Ca²⁺ concentration and in turn, Ca²⁺ signaling regulates the expression of EMT markers. Also, activation of Ca²⁺ signaling genes with epigenetic inhibitors reverts the EMT. Thus, Ca²⁺ signaling might have an important role in breast cancer metastasis and EMT, particularly through the epigenetic regulation of genes involved in its signaling. However, little is known due to that an estimate of 1670 genes participate i

SUBMITTER: Hernandez-Oliveras A 

PROVIDER: S-EPMC9411462 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature