The role of BDNF in mediating the prophylactic effects of (R,S)-ketamine on fear generalization and extinction.

ABSTRACT: Fear generalization is a conserved survival mechanism that can become maladaptive in the face of traumatic situations, a feature central to certain anxiety disorders including posttraumatic stress disorder (PTSD). However, the neural circuitry and molecular mechanisms underlying fear generalization remain unclear. Recent studies have shown that prophylactic treatment with (R,S)-ketamine confers protective effects in stress-induced depressive behaviors and enhances contextual fear discrimination, but the extent to which these effects extend to fear generalization after auditory fear conditioning remains unclear. Here, we build on this work by using a behavioral model of fear generalization in mice involving foot shocks with differential intensity levels during auditory fear conditioning. We

SUBMITTER: Ryan JD 

PROVIDER: S-EPMC9411535 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature