Toxicity mechanisms of aflatoxin M₁ assisted with molecular docking and the toxicity-limiting role of trans-resveratrol.

ABSTRACT: In this study, AFM₁ toxicity and the protective role of trans-resveratrol (t-rsv) against this toxicity were investigated with the help of multiple parameters in albino mice. As a result, AFM₁ (16 mg/kg b.w) administration caused a decrease in body, kidney and liver weights. This reduction was associated with a decrease in feed consumption. AFM₁ induced an increase in AST and ALT enzyme parameters and BUN, creatinine and MDA levels and a decrease in GSH levels. These increases have been associated with liver and kidney cell damage. AFM₁ decreased MI and encouraged increases in MN and CAs numbers. The decrease in MI was correlated with AFM1-tubulin and the increase in CAs was associated with the AFM₁-DNA interaction, which was demonstra

SUBMITTER: Guc I 

PROVIDER: S-EPMC9411558 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature