Broad clinical manifestations of polygenic risk for coronary artery disease in the Women's Health Initiative.

ABSTRACT:

Background

The genetic basis for coronary artery disease (CAD) risk is highly complex. Genome-wide polygenic risk scores (PRS) can help to quantify that risk, but the broader impacts of polygenic risk for CAD are not well characterized.

Methods

We measured polygenic risk for CAD using the meta genomic risk score, a previously validated genome-wide PRS, in a subset of genotyped participants from the Women's Health Initiative and applied a phenome-wide association study framework to assess associations between the PRS and a broad range of blood biomarkers, clinical measurements, and health outcomes.

Results

Polygenic risk for CAD is associated with a variety of biomarkers, clinical measurements, behaviors, and diagnoses related to traditional risk factors, as well as ri

SUBMITTER: Clarke SL 

PROVIDER: S-EPMC9411562 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature