Intestinal tissue-resident T cell activation depends on metabolite availability.

ABSTRACT: The metabolic capacity of many cells is tightly regulated and can adapt to changes in metabolic resources according to environmental changes. Tissue-resident memory (T_RM) CD8⁺ T cells are one of the most abundant T cell populations and offer rapid protection against invading pathogens, especially at the epithelia. T_RM cells metabolically adapt to their tissue niche, such as the intestinal epithelial barrier. In the small intestine, the types of T_RM cells are intraepithelial lymphocytes (IELs), which contain high levels of cytotoxic molecules and express activation markers, suggesting a heightened state of activation. We hypothesize that the tissue environment may determine IEL activity. We show that IEL activation, in line with its semiactive sta

SUBMITTER: Konjar S 

PROVIDER: S-EPMC9411733 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature