Potential of histone deacetylase inhibitors in the control and regulation of prostate, breast and ovarian cancer.

ABSTRACT: Histone deacetylases (HDACs) are enzymes that play a role in chromatin remodeling and epigenetics. They belong to a specific category of enzymes that eliminate the acetyl part of the histones' -N-acetyl lysine, causing the histones to be wrapped compactly around DNA. Numerous biological processes rely on HDACs, including cell proliferation and differentiation, angiogenesis, metastasis, gene regulation, and transcription. Epigenetic changes, specifically increased expression and activity of HDACs, are commonly detected in cancer. As a result, HDACi could be used to develop anticancer drugs. Although preclinical outcomes with HDACs as monotherapy have been promising clinical trials have had mixed results and limited success. In both preclinical and clinical trials, however, combination thera

SUBMITTER: Pramanik SD 

PROVIDER: S-EPMC9411967 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature