Left ventricular noncompaction: a disorder with genotypic and phenotypic heterogeneity-a narrative review.

ABSTRACT:

Background and objective

Left ventricular noncompaction (LVNC) is a cardiomyopathy characterized by excessive trabecular formation and deep recesses in the ventricular wall, with a bilaminar structure consisting of an endocardial noncompaction layer and an epicardial compacted layer. Although genetic variants have been reported in patients with LVNC, understanding of LVNC and its pathogenesis has not yet been fully elucidated. We addressed the latest findings on genes reported to be associated with LVNC morphogenesis and possible pathologies to understand the diverse spectrum between genotype and phenotype in LVNC. Also, the latest findings and issues related to the diagnosis of LVNC were summarized.

Methods

This article is written as a commentary narrative review and will p

SUBMITTER: Hirono K 

PROVIDER: S-EPMC9412206 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature