Comparing Kidney Health Outcomes in Children, Adolescents, and Adults With Focal Segmental Glomerulosclerosis.

ABSTRACT:

Importance

Focal segmental glomerulosclerosis (FSGS) is a common cause of end-stage kidney disease (ESKD) across the lifespan. While 10% to 15% of children and 3% of adults who develop ESKD have FSGS, it remains uncertain whether the natural history differs in pediatric vs adult patients, and this uncertainty contributes to the exclusion of children and adolescents in clinical trials.

Objective

To examine whether there are differences in the kidney health outcomes among children, adolescents, and adults with FSGS.

Design, setting, and participants

This cohort study used pooled and parallel analyses, completed July 5, 2022, from 3 complimentary data sources: (1) Nephrotic Syndrome Rare Disease Clinical Research Network (NEPTUNE); (2) FSGS clinical trial (FSGS-CT); and

SUBMITTER: Gipson DS 

PROVIDER: S-EPMC9412226 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature