Chemerin plasma levels are increased in COVID-19 patients and are an independent risk factor of mortality.

ABSTRACT:

Background

Chemerin is an extracellular protein with chemotactic activities and its expression is increased in various diseases such as metabolic syndrome and inflammatory conditions. Its role in lung pathology has not yet been extensively studied but both known pro- and anti-inflammatory properties have been observed. The aim of our study was to evaluate the involvement of the chemerin/ChemR23 system in the physiopathology of COVID-19 with a particular focus on its prognostic value.

Methods

Blood samples from confirmed COVID-19 patients were collected at day 1, 5 and 14 from admission to Erasme Hospital (Brussels - Belgium). Chemerin concentrations and inflammatory biomarkers were analyzed in the plasma. Blood cells subtypes and their expression of ChemR23 were determined b

SUBMITTER: Lavis P 

PROVIDER: S-EPMC9412239 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature