B₀ Correction for 3T Amide Proton Transfer (APT) MRI Using a Simplified Two-Pool Lorentzian Model of Symmetric Water and Asymmetric Solutes.

ABSTRACT: Amide proton transfer (APT)-weighted MRI is a promising molecular imaging technique that has been employed in clinic for detection and grading of brain tumors. MTR_asym, the quantification method of APT, is easily influenced by B₀ inhomogeneity and causes artifacts. Current model-free interpolation methods have enabled moderate B₀ correction for middle offsets, but have performed poorly at limbic offsets. To address this shortcoming, we proposed a practical B₀ correction approach that is suitable under time-limited sparse acquisition scenarios and for B₁ ≥ 1 μT under 3T. In this study, this approach employed a simplified Lorentzian model containing only two pools of symmetric water and asymmetric solutes, to describe the Z-spectral shap

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9412582 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature