On the relationship between tripartite motif-containing 22 single-nucleotide polymorphisms and COVID-19 infection severity.

ABSTRACT:

Background

The tripartite motif containing (TRIM)-22 participates in innate immune responses and exhibits antiviral activities. The present study aimed to assess of the relationship between TRIM22 single-nucleotide polymorphisms and clinical parameters with the coronavirus disease 2019 (COVID-19) infection severity.

Methods

TRIM22 polymorphisms (rs7113258, rs7935564, and rs1063303) were genotyped using TaqMan polymerase chain reaction (PCR) assay in 495 dead and 497 improved severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients.

Results

In this study, the frequencies of TRIM22 rs1063303 GG, rs7935564 GG, and rs7113258 TT were significantly higher in dead patients than in improved patients, and higher viral load with low PCR Ct value was notice

SUBMITTER: Raheem Juhi Al-Kaabi N 

PROVIDER: S-EPMC9412778 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature