Understanding the pH Dependence of Supersaturation State-A Case Study of Telmisartan.

ABSTRACT: Creating supersaturating drug delivery systems to overcome the poor aqueous solubility of active ingredients became a frequent choice for formulation scientists. Supersaturation as a solution phenomenon is, however, still challenging to understand, and therefore many recent publications focus on this topic. This work aimed to investigate and better understand the pH dependence of supersaturation of telmisartan (TEL) at a molecular level and find a connection between the physicochemical properties of the active pharmaceutical ingredient (API) and the ability to form supersaturated solutions of the API. Therefore, the main focus of the work was the pH-dependent thermodynamic and kinetic solubility of the model API, TEL. Based on kinetic solubility results, TEL was observed to form a supersat

SUBMITTER: Kadar S 

PROVIDER: S-EPMC9412861 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature