-Omic Approaches and Treatment Response in Rheumatoid Arthritis.

ABSTRACT: Rheumatoid arthritis (RA) is an inflammatory disorder characterized by an aberrant activation of innate and adaptive immune cells. There are different drugs used for the management of RA, including disease-modifying antirheumatic drugs (DMARDs). However, a significant percentage of RA patients do not initially respond to DMARDs. This interindividual variation in drug response is caused by a combination of environmental, genetic and epigenetic factors. In this sense, recent -omic studies have evidenced different molecular signatures involved in this lack of response. The aim of this review is to provide an updated overview of the potential role of -omic approaches, specifically genomics, epigenomics, transcriptomics, and proteomics, to identify molecular biomarkers to predict the clinical e

SUBMITTER: Madrid-Paredes A 

PROVIDER: S-EPMC9412998 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature