Alcohol and cannabis co-use and longitudinal gray matter volumetric changes in early and late adolescence.

ABSTRACT:

Background

Previous studies have characterized the impact of substance use on cerebral structure and function in adolescents. Yet, the great majority of prior studies employed a small sample, presented cross-sectional findings, and omitted potential sex differences.

Methods

Using data based on 724 adolescents (370 females) curated from the NCANDA study, we investigated how gray matter volumes (GMVs) decline longitudinally as a result of alcohol and cannabis use. The impacts of alcohol and cannabis co-use and how these vary across assigned sex at birth and age were examined. Brain imaging data comprised the GMVs of 34 regions of interest and the results were evaluated with a Bonferroni correction.

Results

Mixed-effects modeling showed faster volumetric declines in the

SUBMITTER: Luo X 

PROVIDER: S-EPMC9413216 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature