A Ribonucleotide ↔ Phosphoramidate Reaction Network Optimized by Computer-Aided Design.

ABSTRACT: A growing number of out-of-equilibrium systems have been created and investigated in chemical laboratories over the past decade. One way to achieve this is to create a reaction cycle, in which the forward reaction is driven by a chemical fuel and the backward reaction follows a different pathway. Such dissipative reaction networks are still relatively rare, however, and most non-enzymatic examples are based on the carbodiimide-driven generation of carboxylic acid anhydrides. In this work, we describe a dissipative reaction network that comprises the chemically fueled formation of phosphoramidates from natural ribonucleotides (e.g., GMP or AMP) and phosphoramidate hydrolysis as a mild backward reaction. Because the individual reactions are subject to a multitude of interconnected parameters

SUBMITTER: Englert A 

PROVIDER: S-EPMC9413217 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature