Engineering of MSC-Derived Exosomes: A Promising Cell-Free Therapy for Osteoarthritis.

ABSTRACT: Osteoarthritis (OA) is characterized by progressive cartilage degeneration with increasing prevalence and unsatisfactory treatment efficacy. Exosomes derived from mesenchymal stem cells play an important role in alleviating OA by promoting cartilage regeneration, inhibiting synovial inflammation and mediating subchondral bone remodeling without the risk of immune rejection and tumorigenesis. However, low yield, weak activity, inefficient targeting ability and unpredictable side effects of natural exosomes have limited their clinical application. At present, various approaches have been applied in exosome engineering to regulate their production and function, such as pretreatment of parental cells, drug loading, genetic engineering and surface modification. Biomaterials have also been prove

SUBMITTER: Cheng J 

PROVIDER: S-EPMC9413347 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature