Identification of a Suitable Untargeted Agent for the Clinical Translation of ABY-029 Paired-Agent Imaging in Fluorescence-Guided Surgery.

ABSTRACT:

Purpose

Non-specific uptake and retention of molecular targeted agents and heterogeneous tissue optical properties diminish the ability to differentiate between tumor and normal tissues using molecular targeted fluorescent agents. Paired-agent imaging (PAI) can increase the diagnostic ability to detect tumor tissue by mitigating these non-specific effects and providing true molecular contrast by co-administration of an untargeted control imaging agent with a targeted agent. This study evaluates the suitability of available clinically translatable untargeted agents for the translation of PAI in fluorescence-guided surgery using an affibody-based targeted imaging agent (ABY-029).

Experimental

DESIGN: Three untargeted agents that fluoresce near 700 nm and exhibit good clinical

SUBMITTER: Wang C 

PROVIDER: S-EPMC9413473 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature