Lung-Based, Exosome Inhibition Mediates Systemic Impacts Following Particulate Matter Exposure.

ABSTRACT: Particulate matter (PM) exposure is a global health issue that impacts both urban and rural communities. Residential communities in the Southwestern United States have expressed concerns regarding the health impacts of fugitive PM from rural, legacy mine-sites. In addition, the recent literature suggests that exosomes may play a role in driving toxicological phenotypes following inhaled exposures. In this study, we assessed exosome-driven mechanisms and systemic health impacts following inhaled dust exposure, using a rodent model. Using an exosome inhibitor, GW4869 (10 μM), we inhibited exosome generation in the lungs of mice via oropharyngeal aspiration. We then exposed mice to previously characterized inhaled particulate matter (PM) from a legacy mine-site and subsequently assessed downs

SUBMITTER: Lopez K 

PROVIDER: S-EPMC9413489 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature